Possibilities of using nuclear magnetic resonance as a therapeutic adjuvant in the treatment of degenerative-dystrophic joint diseases

February 22, 2024
549
Resume

Nuclear magnetic resonance therapy is a new non-invasive treatment method that can be a supplement or alternative to traditional pharmacological and physiotherapeutic methods. Considering the relative novelty of the technique, research into the possibilities of its use is relevant.

Purpose: to conduct an analysis of data from modern literature regarding the possibility of using nuclear magnetic resonance therapy in the treatment of degenerative-dystrophic joint diseases.

Results. The results of the experimental studies presented in the review prove the stimulating effect of nuclear magnetic resonance therapy on the regenerative potential of cartilage and bone tissues by inducing the proliferation of chondrocytes and osteoblasts. According to the data of clinical studies, the use of nuclear magnetic resonance therapy helped to reduce the intensity of the pain syndrome and improve the functional activity of patients with degenerative-dystrophic diseases of the joints.

Conclusion. Considering the results of the considered experimental and clinical studies, the use of nuclear magnetic resonance therapy is a promising direction in the treatment of degenerative-dystrophic joint diseases. However, it is necessary to conduct further research to deepen knowledge about the mechanism of action of nuclear magnetic resonance therapy in osteoarthritis and the possibilities of using this method in practice.

References

  • 1. Levers A., Staat M., van Laack W. (2011) Analysis of the Long-term Effect of the MBST® Nuclear Magnetic Resonance Therapy on Gonarthrosis. Orthopedic Practice, 47(11): 521–528. DOI:10.21269/302.
  • 2. Krpan D. (2018) MBST — Nuclear Magnetic Resonance Therapy in the Treatment of Osteoarthritis, the Long-Term Follow Up — Case Report. Biomed. J. Sci. Tech. Res., 11(2): 8373–8375. DOI: 10.26717/BJSTR.2018.11.002068.
  • 3. Huels N., Harms O., Keim D. et al. (2020) Treatment of the Clinical Symptoms of Osteoarthritis in the Elbow Joints of Dogs Using Nuclear Magnetic Resonance Therapy: A Randomized, Double-Blinded Trial. Front. Vet. Sci., 7: 500278. doi: 10.3389/fvets.2020.500278.
  • 4. Steinecker-Frohnwieser B., Lohberger B., Eck N. et al. (2021) Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28/2a Cells. Int. J. Mol. Sci., 22(11): 5959. doi.org/10.3390/ijms22115959.
  • 5. Martel-Pelletier J., Barr A.J., Cicuttini F.M. et al. (2016) Osteoarthritis. Nat. Rev. Dis. Primers, 2: 16072. doi.org/10.1038/nrdp.2016.72.
  • 6. Magnetic resonance therapy for knee osteoarthritis [IPG702] (2021) Interventional procedures guidance. NICE guidance National Institute for Health and Care Excellence, 1–5. http://www.nice.org.uk/guidance/ipg702.
  • 7. Krpan D., Kullich W. (2017) Nuclear magnetic resonance therapy (MBST) in the treatment of osteoporosis. Case report study. Clin. Cases Miner. Bone Metab., 14(2): 235–238. doi: 10.11138/ccmbm/2017.14.1.235.
  • 8. Kullich W., Schwann H., Walcher J., Machreich K. (2006) The effect of MBST®-NuclearResonanceTherapy with a complex 3-dimensional electromagnetic nuclear resonance field on patients with Low Back Pain. J. Back Musculoskeletal Rehab., 19(2–3): 79–87. doi:10.3233/bmr-2006-192-307.
  • 9. Ковальський О.В., Мечев Д.С., Данилевич В. П. (2017) Радіологія. Променева терапія. Променева діагностика, 2-ге вид. Нова Книга, 512 с.
  • 10. Auerbach B., Melzer Chr. (2003) Evaluation of the effectiveness of MBST®-NuclearMagnetic Resonance Therapy. Waldkrankenhaus Bad Dueben, Clinic for Orthopaedics, 1–7. medtec.co.il/wp-content/uploads/2021/01/Effectivity_Research.pdf.
  • 11. Jansen H., Frey S.P., Paletta J., Meffert R.H. (2011) Effects of low-energy NMR on posttraumatic osteoarthritis: observations in a rabbit model. Arch. Orthopaed. Trauma Surg., 131(6): 863–868. doi.org/10.1007/s00402-010-1205-1.
  • 12. Choi M.C., Jo J., Park J. et al. (2019) NF-κB signaling pathways in osteoarthritic cartilage destruction. Cells, 8: E734.
  • 13. Khan N.M., Haqqi T.M. (2018) Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. Pharmacol. Res., 128: 73–79.
  • 14. Mucha M., Virac I., Lang C. et al. (2017) Treatment of the clinical symptoms caused by osteoarthritis using nuclear magnetic resonance (MBST®) in dogs-a randomized trial. Wien Tierarztl Monatsschr., 104: 109–115. doi: 10.1186/s12917-016-0840-3.
  • 15. Kljaić K., Kiseljak D., Krpan D. (2016) Rehabilitation of knee osteoarthritis — comparison study: Nuclear magnetic resonance therapy (MBST) versus conventional physiotherapy». Fiz. Rehab. Med., 28(3–4): 364–365. hrcak.srce.hr/234807.
  • 16. Gökşen N., Çaliş M., Doğan S. et al. (2016) Magnetic resonance therapy for knee osteoarthritis: a randomized, double blind placebo controlled trial. Eur. J. Phys. Rehabil. Med., 52(4): 431–439.
  • 17. Schmidt J.K., Debess J.E., Møller L. (2021) Magnetic resonance therapy in the treatment of osteoarthritis: A scoping review. Radiography (Lond.), 27(3): 968–975. doi.org/10.1016/j.radi.2021.02.011.