Treatment of Parkinson’s disease: the potential of extended-release pramipexole

Given the current clinical guidelines, according to which the main goal of treatment of patients with Parkinson’s disease is to correct the deficiency of endogenous dopamine in the nigrostriatal part of the brain, the gold standard of treatment of this neurodegenerative pathology is considered to be levodopa. However, its long-term use leads to severe secondary side effects. The use of modern non-ergoline dopamine receptor agonists, which differ from levodopa in mechanism of action, may be a clinical solution for patients with motor disorders and levodopa-induced dyskinesias. Previous studies have shown the efficacy of the synthetic non-ergoline dopamine receptor agonist pramipexole as the drug of choice in the early stages of Parkinson’s disease. The advantage of using the new oral form of pramipexole with extended release is a significant reduction in the severity of clinical symptoms of motor disorders by achieving and maintaining a stable concentration of dopamine in blood plasma throughout the day. The publication is devoted to the analysis of the efficacy and safety of pramipexole both in monotherapy and in combination with levodopa, in the treatment of patients with early and late stages of the Parkinson’s disease. Particular attention is paid to the study of the effects of pramipexole on rest tremor and depressive disorders in patients with Parkinson’s disease.

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