The patterns of the viral hepatitis C epidemic process in Sumy region

November 20, 2020
750
Resume

The work is devoted to the research patterns of epidemic process of viral hepatitis C (VHC) development in Sumy region in 1991–2019. A complex of descriptive, evaluative and analytical techniques of the epidemiological research method in combination with the methods of mathematical statistics are used in the study. The dynamics and intensity of the VHC epidemic process, as well as the leading routes of pathogen transmission, high-risk territories and population groups have been established. The attempt to assess the scale of the latent epidemiological process of VHC in Sumy region, as well as to explain the reasons for the observed trends in the dynamics of acute and chronic VHC was made. The following epidemiological features of VHC on the territory of the Sumy region in the period 1991–2019 were established: 25-fold increase in incidence rates against the background of a decrease in the activity of the transmission mechanism, a moderate decline in acute VHC and a simultaneous moderate increase in its chronic form, 35-fold reduction in the scale of the latent epidemiological process, two-fold prevalence of the incidence of men in comparison with the incidence of women, significant reduction in chronic and moderate reduction in acute VHC among children, low efficiency of epidemiological investigations of VHC cases and significant unevenness of the territorial distribution of cases of this infection.

References:

  • State Institution «Ukrainian Monitoring and Medical Center for Drugs and Alcohol of the Ministry of Health of Ukraine» (2017) National report for 2017 on the drug situation in Ukraine (according to 2016). In-depth review of the drug situation in Ukraine for the European Monitoring Center for Drugs and Drug Addiction (http://aph.org.ua/wp-content/uploads/2017/11/National-report-2017.pdf).
  • Tretskaya T.A. (1993) Etiological structure of acute viral hepatitis and the frequency of detection of markers of hepatitis A, B, C in groups of high risk of infection and among the population of Ukraine. Author’s ref. dis. … kand. med. sci. Moscow, 23 р.
  • Shaginyan V.R. (2007) The role of the perinatal transmission route in the spread of hepatitis B and C in Ukraine and the improvement of the epidemiological surveillance system. Author’s ref. dis. … Dr. med. sci. Kyiv, 34 p.
  • Shaginyan V.R., Gural A.L., Sergeeva T.A., Myshko O.V. (2012) Vaccination against hepatitis B and the epidemic process of hepatitis B in Ukraine. Vaccine prophylaxis, 6 (67): 52–58.
  • Baden R., Rockstroh J.K., Buti M. (2014) Natural History and Management of Hepatitis C: Does Sex Play a Role? J. Inf. Dis., 209(3): 81–85.
  • Carreño V. (2006) Occult hepatitis C virus infection: a new form of hepatitis C. World J. Gastroenerol., 12(43): 6922–6925. Doi:10.3748/wjg.v12.i43.2000.
  • Castillo I., Rodríguez-Iñigo E., Bartolomé J. et al. (2005) Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Gut, 54(5): 682–685. Doi: 10.1136/gut.2004.057281.
  • CDC United States (2013) Surveillance for Viral Hepatitis. Division of Viral Hepatitis and National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (https://www.cdc.gov/hepatitis).
  • Crowley D., Murtagh R., Cullen W. (2019) Hepatitis C virus infection in Irish drug users and prisoners — a scoping review. BMC infectious diseases, 19(1): 702. Doi: 10.1186/s12879-019-4218-6.
  • ECDC EU (2017) Surveillance of hepatitis B and C in the EU/EEA (https://www.slideshare.net/ECDC_EU).
  • Evans J.L., Hahn J.A., Page-Shafer K. et al. (2003) Gender differences in sexual and injection risk behavior among active young injection drug users in San Francisco (the UFO Study). J. Urban. Health, 80: 137–416. Doi: 10.1093/jurban/jtg137.
  • Lin H., Chen X., Zhu S.P. et al. (2016) Prevalence of Occult Hepatitis C Virus Infection among Blood Donors in Jiangsu, China. Intervirol., 59: 204—210. Doi: 10.1159/000455854.
  • Lingala S. (2015) Natural History of Hepatitis C. Gastroenterol Clin. North. Am., 44(4): 717–734. Doi: 10.1016/j.gtc.2015.07.003.
  • Stepanova M., Younossi Z.M. (2017) Economic Burden of Hepatitis C. Infection Clin. Liver Dis., 21(3): 579–594. Doi: 10.1016/j.cld.2017.03.012.
  • World Health Organization (2016) Global Health Sector Strategies on Viral Hepatitis in 2016–2021 (https://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/).
  • World Health Organization (2017) Global Hepatitis Report 2017 (https://apps.who.int/iris/handle/10665/255016).
  • Wu H.X., Wu J., Wong T. et al. (2006) Enhanced surveillance of newly acquired hepatitis C virus infection in Canada, 1998 to 2004. Scand. J. Infect. Dis., 38(6–7): 482–489. Doi: 10.1080/00365540500525161.