Comparative characteristics of epidemiology and clinics of multiple sclerosis in the south and north of Ukraine on the example of populations of the Nikolaev and Rivne regions | Ukrainian Medical Journal

Stoyanov O.M.,Ivaniuk A.V.,Grinchiuk A.D.,Borisenko O.A.,Bocherova T.I.

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Comparative characteristics of epidemiology and clinics of multiple sclerosis in the south and north of Ukraine on the example of populations of the Nikolaev and Rivne regions

Comparative characteristics of epidemiology and clinics of multiple sclerosis in the south and north of Ukraine on the example of populations of the Nikolaev and Rivne regions

January 23, 2020

735

Neurology and Psychiatry

Keywords :

female-to-male ratio,

multiple sclerosis,

onset,

prevalence

Specialities :

Neurology and Psychiatry

Resume

Aim — to analyze the epidemiological and clinical features of multiple sclerosis (MS) in patients living in the south and north of Ukraine using the populations of Nikolaev and Rivne regions. Methods. A descriptive cross-sectional study was conducted using clinical and epidemiological data of all MS patients registered in 11 districts of the Nikolaev region (DNR, n=118) and 3 districts of the Rivne region (DRR, n=105) with the same total population as of 2018 year. Data was collected using structured questionnaires sent to district medical institutions. The data obtained were analyzed by descriptive statistics using the χ² to determine the significance of differences between groups. Results. The female-to-male ratio for DNR was 1.62, for DRR — 1.56. In both regions, MS onset most often occurred at the age of 21–30 years (42.4 and 40.0% in DNR and DRR, respectively). In 72.0% of patients in DNR and 60.5% — in DRR, there was a gradual development of symptoms at the onset. The majority of DNR patients had polysymptomatic (74.6%) and monosymptomatic (11.0%) MS onset compared to DRR patients (66.7 and 7.6%, respectively; p=0.09). Significantly more patients in DNR had a secondary progressive phenotype (47 (39.0%) compared with DRR (14 (13.3%); p<0.00001). The number of relapses per year and Expanded Disability Status Scale (EDSS) index did not significantly differ between the groups. Conclusions. In contrast to DRR patients, DNR patients showed a tendency toward polysymptomatic onset of MS. Significantly more patients with DNR had a secondary progressive course, while in the DRR a relapsing-remitting phenotype prevailed. The female-to-male ratio, the age of the onset, the number of exacerbations per year, and the EDSS index did not differ significantly between the patients of the two regions.

Published: 23.01.2020

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