Features of functioning of local immunity in children with undifferentiated connective tissue dysplasia | Ukrainian Medical Journal

Vovk V.M.,Oshlyanskaya O.A.

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Features of functioning of local immunity in children with undifferentiated connective tissue dysplasia

Features of functioning of local immunity in children with undifferentiated connective tissue dysplasia

May 10, 2018

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Aim — to analyze the relationship between the indices of cellular and humoral local immunity, individual indices of the cytokine profile in children with and without undifferentiated connective tissue dysplasia (UCTD). Object and methods. Correlation and multifactorial analysis of the state of humoral immunity (immunoenzymatic analysis of saliva) and cellular immunity (immunocytochemical and morphological study of scrapings from palatine tonsils) in 40 children, which are observed at the medical center «Dobrobut». Results. The lower levels in the saliva of IL-4, IL-10, IgA, component of compliment C3 and a higher level of IgG, as well as lower levels of expression of antigens to IgA, markers of macrophages CD68, CD16 in scrapings from palatine tonsils were noted in children with clinical signs of UCTD. There was a close correlation between the level of expression of antigens to IgA and IgG content in saliva (r=0.50), as well as its feedback with the ratio IL-10/(IgA + IgG in g/l) (r=–0.86), with the content of IL-4 in saliva (r=–0.84) and IL-10 in saliva (r=–0.83), with the ratio of cytokines IL-10 IL-4 (r=–0.53), IL-10/IN-γ (r=–0.83), the compliment component C3 (r=–0.61). Conclusions. The study showed, that children with clinical manifestations of UCTD have a reduced potential of the humoral link of local immunity and latent insufficiency of cellular local immunity, which requires additional correction.

O.A. Oshlyanskaya, V.M. Vovk

Key words: children, undifferentiated connective tissue dysplasia, local immunity, cytokines, immunoglobulins, palatine tonsils.

Published: 15.05.2018

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