Association of paternal/maternal combinations of MTHFR, MTRR, MTR1 genes in risk of development the reproductive disorders in married couples | Ukrainian Medical Journal

Gorovenko N.G.,Kyriachenko S.P.,Rossokha Z.I.

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Association of paternal/maternal combinations of MTHFR, MTRR, MTR1 genes in risk of development the reproductive disorders in married couples

Association of paternal/maternal combinations of MTHFR, MTRR, MTR1 genes in risk of development the reproductive disorders in married couples

December 3, 2018

911

Obstetrics and Gynecology

Genetic and Regenerative medicine

Gorovenko N.G.

Kyriachenko S.P.

Rossokha Z.I.

Specialities :

Obstetrics and Gynecology

Genetic and Regenerative medicine

Resume

Aim — to investigate the combinations of paternal and maternal genotypes of MTHFR (C677T, rs1801133 and A1298C, rs1801131), MTRR (A66G, rs1801394), MTR1 (A2756G, rs1805087) genes in the development of early reproductive losses and unspecified infertility. The object and methods of research. Molecular genetic studies of MTHFR (C677T, rs1801133; A1298C, rs1801131), MTRR (A66G, rs1801394), MTR1 (A2756G, rs1805087) were performed in 206 married couples with reproductive disorders and 35 married couples of the comparison group. The analysis of genotype combinations frequency was carried without and with define genotypes origin in the married couple: paternal (p) or maternal (m). Results. The combination of 1298AA paternal genotype аnd 1298CC maternal genotype in MTHFR gene were associated with increased risk of infertility, and 66GG paternal genotype with 66AG maternal genotype in MTRR gene — with reproductive losses. On the contrary, the development risk of reproductive disorders was significantly reduced in the presence of parental couple combinations genotypes: 66AA+66AA in MTRR gene and 2756AA+2756AA in MTR1 gene. The were determind significant genetic risk 6-locus models of unspecified infertility (MTRR_A66G (р)/MTRR_A66G (m)/MTHFR_C677T (р)/MTHFR_C677T (m)/MTHFR_A1298C
(р)/MTR1_A2756G (m)) and early pregnancy loss (MTRR_A66G (р)/MTRR_A66G (m)/MTHFR_С677T (р)/MTHFR_A1298C
(р)/MTR1_A2756G (р)/MTR1_A2756G (m)), with predictive value 63.72% and 64.89%, respectively.

Published: 03.12.2018

References:

Veropotvelyan N.P., Pogulyay Yu.S., Kodunov L.O. (2011) Osobennosti raspredeleniya polimorfnyih genov sistemyi HLAII klassa, folatnogo obmena, faktorov svertyivaemosti krovi u supruzheskih par s privyichnyim nevyinashivaniem beremennosti. Neonatol. hir. perinat. med., 1(1): 82–84.
Rossokha Z.I., Kyriachenko S.P., Horovenko N.H. (2018) Rol mizhhennoi vzaiemodii MTHFR, MTRR, MTR1 u rozvytku porushen folatnoho obminu u patsiientok iz reproduktyvnymy rozladamy. Ukr. med. chasopys, 3(2)(125): 35–39.
Furness D. (2018) Vitamin and mineral supplements: maternal diet and nutrient requirements in pregnancy and lactation. AJP, 99(1177): 76–84.
Hong H.H., HuY., Yu X.Q. et al. (2017) Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: a meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol., 212: 101–109.
LeBlanc D.P. (2017) The effect of dietary folic acid intake on somatic and germ cell mutations in the transgenic Muta Mouse model. Ottawa, Ontario, Carleton University, 110 p.
Neagoş D., CreŃu R., Sfetea R. et al. (2012) Investigation of the relationship between the risk of spontaneous abortion and C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene. Rev. Rom. Med. Lab., 20(4): 335–343.
Nowak I., Bylińska A., Wilczyńska K. et al. (2017) Themethylenetetrahydrofolatereductase c.c.677 C>T and c.c.1298 A>C polymorphisms in reproductive failures: experience from an RSA and RIF study on a Polish population. PLoS ONE, 12(10): e0186022.
Sah A.K., Shrestha N., Joshi P. et al. (2018) Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss. BMC Res. Notes, 11: 233.
Tara S.S., Ghaemimanesh F., Zarei S.F. et al. (2015) Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in male partners of recurrent miscarriage couples. J. Reprod. Infertil., 16(4): 193–198.
Vidyadharia M., Sujathaa M., Krupab P., Venkateshwari A. (2018) A family based triad study evaluating the role of MTHFR gene polymorphisms in spontaneous abortions. Gene Reports., 10: 116–122.
Xu W., Zhang L.Wu X., Jin F. (2017) Association between methionine synthase reductase A66G polymorphism and male infertility: a neta-analysis, 27(1): 37–46.