Current and effective strategies of treatment the acute ischemic stroke with edaravone: a review of the evidence | Ukrainian Medical Journal

In the adult population, acute ischemic stroke ranks first among various neurological diseases in terms of frequency and disabling effects. The main goal of therapy is not only to prevent the development of recurrent episodes, but also to offset the existing neurological deficit. The article presents the results of new systematic reviews and meta-analyses, data from experimental and clinical studies demonstrating that edaravone has powerful antioxidant properties, its ability to scavenge oxygen free radicals, helping to reduce neuroinflammation, cerebral edema and excessive microglial activation. The ischemic cascade blocker edaravone is used in the complex therapy of cerebrovascular disorders in the acute and subacute periods; its use contributes to the regression of neurological deficits and allows for faster clinical stabilization, accelerated functional recovery, improved prognosis, and reduced risk of death.

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