Polymorphism of CYP2C19*17 isoenzyme as a risk-factor for peptic ulcers induced by the use of nonsteroidal anti- inflammatory drugs

Onischuk L.A.¹, Tkach S.M.²

• ¹National Medical University named after A.A. Bogomolets, Kyiv
• ²Ukrainian Scientific-Practical Center of Endocrine Surgery, Transplantation of endocrine organs and tissues of the Ministry of Health of Ukraine, Kiev

Summary. The new risk-factors for peptic ulcers induced by the use of nonsteroidal anti-inflammatory drugs, such as polymorphism of different isoenzymes of cytochrome P450 were considered in the arti - cle. Based on investigations of 5 different isoenzymes (CYP 2C9*2, CYP 2C9*3, CYP 2C19*2, CYP 2C19*3 and CYP 2C19*17) it was foun ded that peptic ulcers are strictly associated only with CYP 2C19*17-genotype, possibly due to its involvement in arachidonic acid metabolism and gastroprotection. Thus, polymorphism CYP 2C19*17 can be considered as one of the risk factors for NSAID-gastropathy though the future researches are needed.

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