Украинский Медицинский Журнал
Издательство МОРИОН АПТЕКА online Компендиум Клиническая онкология Работа в медицине и фармации
Украинский Медицинский Журнал
  • Home
  • Online
  • Last issue
  • Archive
  • Authors
  • Professional measures
  • Organizations
  • About the Journal
  • Instructions for authors
  • Categories
    • Case report in clinical practice
    • Distance education
    • Events and comments
    • Evidence-based medicine
    • For a medical practitioner
    • Good medical practice
    • History of medicine
    • Medical ethics
    • Medical law
    • News
    • Research article
    • Review
    • Scientific discussions
    • Standards and protocols
    • Topical issue
  • Specialties
    • Allergology and Pulmonology
    • Anesthesiology and Intensive care
    • Cardiology, Rheumatology
    • Dermatology and Venereology
    • Endocrinology
    • Gastroenterology
    • Genetic and Regenerative medicine
    • Healthcare organization
    • Immunology
    • Infectious diseases
    • Medical emergency
    • Medical law
    • Neonatology
    • Nephrology and Urology
    • Neurology and Psychiatry
    • Obstetrics and Gynecology
    • Oncology, Hematology
    • Ophthalmology
    • Orthopedics and Traumatology
    • Otorhinolaryngology
    • Pediatrics
    • Pharmacoeconomics
    • Pharmacology
    • Phthisiology
    • Preventive medicine
    • Radiology
    • Scientific discussions
    • Stomatology
    • Surgery
    • Therapy, General practice
  • Home
  • Online
  • Last issue
  • Archive
  • Authors
  • Professional measures
  • Organizations
  • About the Journal
  • Instructions for authors
  • Categories
    • Case report in clinical practice
    • Distance education
    • Events and comments
    • Evidence-based medicine
    • For a medical practitioner
    • Good medical practice
    • History of medicine
    • Medical ethics
    • Medical law
    • News
    • Research article
    • Review
    • Scientific discussions
    • Standards and protocols
    • Topical issue
  • Specialties
    • Allergology and Pulmonology
    • Anesthesiology and Intensive care
    • Cardiology, Rheumatology
    • Dermatology and Venereology
    • Endocrinology
    • Gastroenterology
    • Genetic and Regenerative medicine
    • Healthcare organization
    • Immunology
    • Infectious diseases
    • Medical emergency
    • Medical law
    • Neonatology
    • Nephrology and Urology
    • Neurology and Psychiatry
    • Obstetrics and Gynecology
    • Oncology, Hematology
    • Ophthalmology
    • Orthopedics and Traumatology
    • Otorhinolaryngology
    • Pediatrics
    • Pharmacoeconomics
    • Pharmacology
    • Phthisiology
    • Preventive medicine
    • Radiology
    • Scientific discussions
    • Stomatology
    • Surgery
    • Therapy, General practice
  • Categories
  • Specialties
  • Case report in clinical practice
  • Distance education
  • Events and comments
  • Evidence-based medicine
  • For a medical practitioner
  • Good medical practice
  • History of medicine
  • Medical ethics
  • Medical law
  • News
  • Research article
  • Review
  • Scientific discussions
  • Standards and protocols
  • Topical issue
  • Allergology and Pulmonology
  • Anesthesiology and Intensive care
  • Cardiology, Rheumatology
  • Dermatology and Venereology
  • Endocrinology
  • Gastroenterology
  • Genetic and Regenerative medicine
  • Healthcare organization
  • Immunology
  • Infectious diseases
  • Medical emergency
  • Medical law
  • Neonatology
  • Nephrology and Urology
  • Neurology and Psychiatry
  • Obstetrics and Gynecology
  • Oncology, Hematology
  • Ophthalmology
  • Orthopedics and Traumatology
  • Otorhinolaryngology
  • Pediatrics
  • Pharmacoeconomics
  • Pharmacology
  • Phthisiology
  • Preventive medicine
  • Radiology
  • Scientific discussions
  • Stomatology
  • Surgery
  • Therapy, General practice
Advertising in the issue 6(1) (140) – XI/XII 2020
  • All electronic publications
6 (122) – XI/XII 2017 :
  • Research article

Diagnostic value of lipoprotein (a) and its indices as markers of significant coronary artery obstruction in patients with stable ischemic heart disease

Bulda V.I.1, Zaretska V.V.2, Mashkovska S.I.2, Svintsitskyi I.A.1

  • 1National Medical University named after A.A. Bogomolets, Kyiv
  • 2State Institution «Institute of the heart of the Ministry of Health of Ukraine», Kyiv

Summary. The aim of the study was to determine the diagnostic value of lipoprotein (a) (Lp (a)) and its indices as markers of significant coronary artery (CA) obstruction in patients with stable ischemic heart disease (IHD). Materials and methods. We performed a single-center cross-sectional study of 61 patients with stable IHD (40 men and 21 women, median age — 67 years). Serum lipid levels, including Lp (a), were determined, lipid tetrad index (LTI) and modified lipid tetrad index (MLTI) were calculated. The patients were divided into two groups according to the presence of significant (n=42) or insignificant (n=19) CA obstruction. Results. Patients with stable IHD and significant epicardial coronary stenosis had statistically significantly higher levels of Lp (a), LTI and MLTI. All of them correlated with the Gensini score and the number of affected coronary segments. ROC-analysis was used to find out the optimal cut-off values for these diagnostic tests: Lp (a) >43 mg/dL (sensitivity — 45.2%, specificity — 94.7%), LTI >7127 (sensitivity — 60%, specificity — 73.7%) and MLTI >6072 (sensitivity — 60%, specificity — 73.7%). Conclusions. Lp (a) has high specificity but low sensitivity for significant CA obstruction detection in patients with stable IHD. Since the diagnostic accuracy of Lp (a), LTI and MLTI is not high, an integrated multi-marker approach using clinical, laboratory and instrumental data is considered promising.

I.A. Svintsitskyi, S.I. Mashkovska, V.V. Zaretska, V.I. Bulda

Key words: stable ischemic heart disease, coronary atherosclerosis, biomarkers, lipoprotein (a), lipid tetrad index, modified lipid tetrad index.

Comments
No Comments » Add own
Leave a comment

If you notice an error select the text with error and press Ctrl + Enter to tell as about it
Full article in pdf format
Specialties:
Cardiology, Rheumatology
Views: 252
Украинский медицинский журнал

«Morion» publishing house
Editorial office and publisher: 02140, Kyiv, ave. Bazhana 10A
Tel.: +380 (44) 585-97-10

Specialized medical online edition for doctors,
pharmacists, students of medical and pharmaceutical universities
Disclaimer

Издательство МОРИОНmorion.ua АПТЕКА onlineapteka.ua Компендиум — справочник лекарств №1compendium.com.ua