Etiologic and pathogenetic factors of dysmethabolic nephropathies in children
Summary. Recently the growth of prevalence of dysmethabolic nephropathy in the structure of kidney morbidity in children is observed. Dysmethabolic nephropathy takes 27–64% among all structure of kidney diseases of children. Data of the literature about the most common factors of pathogenesis of methabolic nephropathy in children were analized. Available scientific sources dedicated to the mechanisms of development of the dysmethabolic nephropathy, studied by the methods of overview and system analyses. The results of the modern studies with description of the inherited and biochemical factors as substantial for origin of the nephropathy, were analyzed, as well as the features in pathogenesis of oxaluria, uraturia and cystinic nephropathy. On the basis of the studied sources it is possible to assert that there is no specific model which can explain pathological changes in different parts of kidney structure depending on direction of action of unfavorable factor. For the exposure of association between interleukin content and the state of mineral methabolism in dysmethabolic nephropathy the further study of patterns obtained on the basis of clinical, laboratory, statistical and epidemiological studies are necessary.
Key words: dysmethbolic nephropathy in kids, oxaluria, uraturia, phosphaturia, interleukins.
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