Evaluation of genetic predictors influence on development risk of chronic generalized catherine gynivitis in children with formation of its phenotypic features

Gorovenko N.G.; Kyriachenko S.P.; Rossokha Z.I.; Savichuk N.O.; Trubka I.A.

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3(2) (125) – V/VI 2018 :

Research article

Evaluation of genetic predictors influence on development risk of chronic generalized catherine gynivitis in children with formation of its phenotypic features

Gorovenko N.G.¹, Kyriachenko S.P.², Rossokha Z.I.³, Savichuk N.O.⁴, Trubka I.A.⁴

¹National Medical Academy of Postgraduate Education named after P.L. Shupik, Kyiv
²SI «Reference center for molecular diagnostics of the Ministry of Health of Ukraine», Kyiv
³Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv
⁴National Medical Academy of Postgraduate Education named by P. L . Shupic of the Ministry of Health of Ukraine

Summary. The effect of GSTT1, GSTM1, IL-1β, MMP-13 genes polymorphism on increased development risk of chronic generalized catarrhal gingivitis (CGCG) in children and formation of its phenotypic features was evaluated in this work. Сlinical study included standard dental examination of 49 school children aged 7–15 years. All children were undergoing Ca, P, acid and alkaline phosphatase, malondialdehyde, catalase biochemical analysis in the oral liquid and molecular genetic study of periodontal pathogens and GSTT1, GSTM1, IL-1β (C3953T), MMP-13 (A77G) polymorphic gene variants. HGKG genetic predictors in children have been identified: deletion polymorphism in GSTT1 gene, 3953СT heterozygous variant in IL-1β gene and genotypes combinations of GSTT1,GSTM1,IL-1β, MMP-13 genes, which modulated disease onset included increased development risk or its decreased. Identified genetic predictors increased HGCG development risk in children due to the combined effects of adverse genes variants with paradontopathogenic infections: Bacteroides forsythus, Treponema denticola, Porphyromonas gingivalis. Genetic polymorphism associated with antioxidant defense and phosphoric-calcium metabolism indicators and their complex influenced on formation of disease phenotype with severe course.

DOI 10.32471/umj.1680-3051.125.126852

I.O. Trubka, Z.I. Rossokha, S.P. Kyriachenko,
N.O. Savychuk, N.G. Gorovenko

Key words: children, chronic generalized catarrhal gingivitis, genes polymorphism.

Published: 05.07.2018

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