Modern approach to pharmacotherapy of gastroesophageal reflux disease in pregnant women

Dragomiretska N.V.; Zabolotna I.B.; Izha G.M.; Kalinichenko M.V.

All electronic publications

1(1) (129) – I/II 2019 :

For a medical practitioner

Modern approach to pharmacotherapy of gastroesophageal reflux disease in pregnant women

Dragomiretska N.V., Zabolotna I.B., Izha G.M., Kalinichenko M.V.

DU "Ukrainian Research Institute of Medical Rehabilitation and Resortology of the Ministry of Health of Ukraine", Odessa

Summary. Gastroesophageal reflux disease is one of the most frequent pathologies in the structure of acid-dependent diseases of the digestive system in different trimesters of pregnancy. A significant decrease in the quality of life of pregnant women, prolonged drug treatment, which leads to various adverse reactions, cause the urgency of this problem. In this regard, for symptomatic treatment of heartburn in pregnant women, the rational choice is Gaviscon® Forte, which contains sodium alginate, which has an adsorbent and enveloping effect. The lack of systemic action and a favorable safety profile allow the use the Gaviscon® Forte in pregnant and lactating women.

DOI doi.org/10.32471/umj.1680-3051.129.137062

Published: 08.02.2019

References:

Kompendium — lekarstvennyie preparatyi (2018) GAVISCON (GAVISCON^®) (https://compendium.com.ua/info/170935/gaviskon/).
Skripnik I.M., Maslova G.S. (2010) Gastroezofagealna reflyuksna hvoroba I vagItnIst. Nov. med. farmats., 323 um — lekarstvennyie preparatyi (2018) (http://www.mif-ua.com/archive/article/12451).
Uspenskiy Yu.P., Baryishnikova N.V., Pahomova I.G. (2009) Klinicheskie perspektivyi ispolzovaniya preparatov na osnove alginovoy kislotyi v lechenii gastroezofagealnoy reflyuksnoy bolezni. RZhGGK (Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii), 2: 79–84.
Berthon G. (2002) Aluminium speciation in relation to aluminium bioavailability, metabolism and toxicity. Coord. Ghem. Rev., 228(2): 319–341.
Dent J., Brun J., Fendrick A.M. et al. (1999) An evidence-based appraisal of reflux disease management — the Genval Workshop Report. Gut, 44 (Suppl. 2): S1–S16.
El-Serag H.B., Graham D.Y., Satia J.A., Rabeneck L. (2005) Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am. J. Gastroenterol., 100(6): 1243–1250.
Gill S.K., O’Brien L., Einarson T.R., Koren G. (2009a) The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis. Am. J. Gastroenterol., 104(6): 1541–1545.
Gill S.K., O’Brien L., Koren G. (2009b) The safety of histamine 2 (H₂) blockers in pregnancy: a meta-analysis. Dig. Dis. Sci., 54(9): 1835–1838.
Kaehny W.D., Hegg A.P., Alfrey A.C. (1977) Gastrointestinal absorption of aluminum from aluminum-containing antacids. N. Engl. J. Med., 296(24): 1389–1390.
Katz P.O., Gerson L.B., Vela M.F. (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am. J. Gastroenterol., 108(3): 308–328.
Lindow S.W., Regnéll P., Sykes J., Little S. (2003) An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy. Int. J. Clin. Pract., 57(3): 175–179.
Majithia R., Johnson D.A. (2012) Are proton pump inhibitors safe during pregnancy and lactation? Evidence to date. Drugs, 72(2): 171–179.
Marrero J.M., Goggin P.M., de Caestecker J.S. et al. (1992) Determinants of pregnancy heartburn. Br. J. Obstet. Gynaecol., 99(9): 731–734.
Naumann C.R., Zelig C., Napolitano P.G., Ko C.W. (2012) Nausea, vomiting, and heartburn in pregnancy: a prospective look at risk, treatment, and outcome. J. Matern. Fetal. Neonatal. Med., 25(8): 1488–1493.
Olans L.B., Wolf J.L. (1994) Gastroesophageal reflux in pregnancy. Gastrointest. Endosc. Clin. N. Am., 4(4): 699–712.
Pasternak B., Hviid A. (2010) Use of proton-pump inhibitors in early pregnancy and the risk of birth defects. N. Engl. J. Med., 363(22): 2114–2123.
Rey E., Rodriguez-Artalejo F., Herraiz M.A. et al. (2007) Gastroesophageal reflux symptoms during and after pregnancy: a longitudinal study. Am. J. Gastroenterol., 102(11): 2395–2400.
Richter J.E. (2011) Heartburn, nausea, vomiting during pregnancy. In: Pregnancy in Gastrointestinal disorders. American college of Gastroenterology, 18–25 pp.
Servey J., Chang J. (2014) Over-the-Counter Medications in Pregnancy. Am. Fam. Physician, 90(8): 548–555.
Uzan M., Uzan S., Sureau C., Richard-Berthe C. (1988) Heartburn and regurgitation in pregnancy. Efficacy and innocuousness of treatment with Gaviscon suspension. Rev. Fr. Gynecol. Obstet., 83(7–9): 569–572.