Association of Pro12Ala polymorphism of PPAR-γ gene with blood biochemical parameters, cytokine and adypokine profiles, structural and functional parameters of liver in patients with nonalcoholic fatty liver disease
- 1Higher State Educational Establishment of Ukraine «Bukovinsky State Medical University», Chernivtsi
- 2State institution «Reference center for molecular diagnostics of the Ministry of Health of Ukraine», Kyiv
- 3National Medical Academy of Postgraduate Education named after PL Shupik, Kyiv
Summary. The association of Pro12Ala polymorphism of PPAR-γ gene and biochemical blood indicators, cytokine and adipokine profiles, structural and functional parameters of liver in patients with nonalcoholic fatty liver disease was investigated. The Ala-allele of PPAR-γ gene prevalence in patients with nonalcoholic fatty liver disease wasn’t significantly different from proper distribution in healthy individuals. The Ala/Ala and Pro/Ala genotype of PPAR-γ gene in patients with nonalcoholic fatty liver disease was associated with significantly higher activity of cytolytic syndrome compared with Pro/Pro-genotype which occurred on the background of similar structural and functional changes in liver. Patients with Ala/Ala and Pro/Ala genotypes were characterized by higher leptin and atrial natriuretic propeptide blood levels compared to patients with Pro/Pro-genotype.